Monday – Sunday 8:30 AM – 5 PM By Appointment

Dr Ashish Sabharwal

Sr. Consultant Urologist, Andrologist & Robotic Surgeon Indraprastha Apollo Hospital, Sarita Vihar, New Delhi -110076 Department Of Urology & Robotic Surgery Gate 10, Room 1003

Gleason score for grading prostate cancer in New Delhi, India

Gleason score for grading prostate cancer in New Delhi, India

Prostate cancer is the most common cancer in men. When your PSA is high and you have done a Prostate biopsy, and a report comes as Gleason 7 (4+3) prostate cancer, you wonder what that means. Is it a good cancer or is it an aggressive cancer. I am Dr Ashish Sabharwal, Prostate Cancer Specialist and Robotic surgeon from Apollo hospital, New Delhi. I did my formal fellowship training in Robotic surgery at University of Miami, USA. I will give full details on significance of Gleason Score in Prostate Cancer.
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What is Gleason Score?

Gleason score tells about the grade of the prostate cancer. It tells about how aggressive the cancer is. Aggressive cancers can spread to the whole body and cause many problems. They can even kill the patient. They do not respond well to a single treatment. They need multimodal treatments for cure or control the cancer.

How is Gleason scoring done?

Prostate cancer cells are always different from a normal healthy cell.

When we see the cells under a microscope, If the cells look similar to the normal cells then they are given score 3 ( Well differentiated ) , if they are slightly different, they are called Gleason 4 (Moderately differentiated ) and if they are totally different, they are called Gleason 5 (Poorly differentiated ).
In the biopsy, 12 cores are taken and we add up the 2 most commonly occurring cells and give a final sum score.

So, the sum score can be:
3+3 : Gleason 6 Well differentiated
3+3 : Gleason 7 Moderately differentiated
3+3 : Gleason 8 Poorly differentiated
3+3 : Gleason 8 Poorly differentiated
3+3 : Gleason 9 Poorly differentiated
3+3 : Gleason 10 Poorly differentiated
So the Gleason grading system starts at 6 and runs to 10. The lowest grade is reported is a 3+3=6 and, the larger the number the more aggressive the cancer.

What to do next after a Gleason score Prostate cancer has been diagnosed?

The next step is staging of prostate cancer. That means that we have to find out if cancer is localised to the prostate or it has spread to any other parts of the body?
The best test for staging of prostate cancer is PSMA PET CT Scan.

What is the life expectancy with Gleason score Prostate cancer diagnosis?

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The good news is that the survival rates with prostate cancer are excellent!
According to the American Cancer Society website:
Of all the men diagnosed with prostate cancer every year:

five-year survival with prostate cancer 99%
ten-year survival with prostate cancer 98%
15-year survival with prostate cancer 94%

There are men however that die from prostate cancer. Why is that?

  1. Some men don’t get screened and they’re diagnosed with very advanced disease at the get-go.
  2. And then there are certain rare subtypes of prostate cancer that behave much more aggressively, and those are the ones that we all hear about.

So, my recommendation is get screened for prostate cancer, diagnose the cancer early and get treated properly, so that you can beat prostate cancer and become a Prostate cancer winner!

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